Arthrogryposis Multiplex Congenita (AMC) is a condition that originates before birth and is noticeable at birth, characterized by restricted movement in multiple joints. Typically, joints in the arms and legs, such as shoulders, elbows, wrists, fingers, hips, knees, ankles, and feet, may have limited or fixed mobility. This condition is often associated with the excessive growth of fibrous tissue within the joints.Previously, AMC was considered a singular disease, but it is now understood to encompass multiple conditions. The underlying causes of AMC are believed to be similar for all types of arthrogryposis, regardless of how many joints are affected. These causes may include neurological deficits, muscle and skeletal abnormalities, fetal crowding or constraint, and certain maternal illnesses.The term "arthrogryposis" is derived from the Greek words "arthro-" meaning joint and "gryposis" meaning crooking, roughly translating to "many crooked joints present at birth."
