Von Willebrand disease is the most prevalent inherited blood clotting disorder, characterized by a deficiency or defect in a clotting protein known as von Willebrand factor. This protein is produced by the cells lining blood vessel walls. There are several types of this disease, all of which impact both men and women. Symptoms may include easy bruising, frequent nosebleeds, gum bleeding after dental work, heavy menstrual periods in women, and blood in stool and urine. Excessive bleeding can also occur following cuts, accidents, or surgeries. The condition is generally mild and often does not require treatment unless triggered by surgery, dental extractions, or accidents. For those in need of treatment, medications like desamino-8-arginine vasopressin (DDAVP) may be administered to boost von Willebrand factor levels and reduce bleeding risk. Antihemophilic factor (Alphanate) can be used to minimize bleeding in patients undergoing surgery or other invasive procedures. Additionally, blood plasma or specific factor VIII preparations might be employed to control bleeding.
