Opiate: A substance, either a medication or an illicit drug, that is extracted from the poppy plant. Opiates act as sedatives that slow down bodily functions, alleviate pain, and promote sleep. Examples of opiates include codeine and morphine. On the other hand, the term "opioid" is more encompassing, originally referring to any natural (like opiates) or synthetic substance that interacts with opioid receptors in the brain, resulting in sedation and pain relief. Synthetic opioids include prescription pain medications such as hydrocodone (Vicodin) and oxycodone (OxyContin), as well as fentanyl and methadone. In recent years, "opioid" has been used more broadly to describe the entire category of drugs, encompassing both natural opium derivatives (opiates) and synthetic opioids. All opioids can cause side effects like excessive sedation, nausea, and constipation. Prolonged use may lead to addiction, and misuse can result in overdose and potentially fatal consequences.